Editors-in-Chief: Eugene V Koonin, National Center for Biotechnology Information, NIH; Laura F Landweber, Princeton University; David J Lipman, National Center Biotechnology Information, NIH
Biology Direct considers original research articles, hypotheses, comments, discovery notes and reviews in selected subject areas, and will eventually cover the full spectrum of biology.
Subject areas already launched include:
- Genomics, Bioinformatics and Systems Biology - Edited by Eugene Koonin, Laura Landweber, & David Lipman
- Immunology - Edited by Neil S Greenspan & David R Kaplan
- Mathematical Biology - Edited by Marek Kimmel.
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Latest articles
Hypothesis
Uniting sex and eukaryote origin in an emerging oxygenic world
Jeferson Gross, Debashish Bhattacharya
Biology Direct 2010, 5:53 (23 August 2010)
[Abstract] [Provisional PDF] [PubMed] [Related articles]
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Accumulation of oxygen during the Archaen might have driven the origin of eukaryotes with evolution of the endomembrane system, mitochondria, sex (meiosis), and the nucleus as responses to oxygen toxicity.
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Research
Encoding the states of interacting proteins to facilitate biological pathways reconstruction
Alberto Termanini, Paolo Tieri, Claudio Franceschi
Biology Direct 2010, 5:52 (13 August 2010)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]
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Research
Measuring gene expression divergence: the distance to keep
Galina Glazko, Arcady Mushegian
Biology Direct 2010, 5:51 (6 August 2010)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]
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Different distance measures may differently group gene expression data, because different trends coexist in the data: e.g., correlation-based distance is better at grouping genes with concerted changes, whereas Euclidean distance is better at finding expression profiles with low divergence.
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Research
A kinetic model of TBP auto-regulation exhibits bistability
Sucheta A Gokhale, Reema Roshan, Vivek Khetan, Beena Pillai, Chetan J Gadgil
Biology Direct 2010, 5:50 (5 August 2010)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]
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Research
Phylogenetic and regulatory region analysis of Wnt5 genes reveals conservation of a regulatory module with putative implication in pancreas development
Maria Kapasa, Stilianos Arhondakis, Sophia Kossida
Biology Direct 2010, 5:49 (4 August 2010)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]
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Although Wnt5 paralogs regulate pancreas formation, they shift roles in different species. In silico analysis confirmed the duplication of Wnt5 gene and revealed a regulatory module involved in pancreas development conserved in at least one Wnt5 paralog.
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